Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation
نویسندگان
چکیده
منابع مشابه
Cranial irradiation inhibits hippocampal neurogenesis via DNMT1 and DNMT3A
Impairment of neurogenesis in the hippocampus following whole-brain irradiation is the most important mechanism of radiation-induced cognitive dysfunction. However, the underlying mechanism remains obscure, meaning an ideal therapeutic target has not been identified. Evidence indicates that DNA methylation in neurons regulates synaptic plasticity and neuronal network activity. In the present st...
متن کاملMeningioma following cranial irradiation.
The case of a middle aged man who developed a meningioma directly underneath the site of a naevus treated with radiotherapy as a child, is presented. Epidemiological evidence and reports of similar cases suggesting meningiomas may be a sequel to irradiation, are reviewed.
متن کاملEffect of acute and fractionated irradiation on hippocampal neurogenesis.
Ionizing radiation has become an inevitable health concern emanating from natural sources like space travel and from artificial sources like medical therapies. In general, exposure to ionizing radiation such as γ-rays is one of the methods currently used to stress specific model systems. In this study, we elucidated the long-term effect of acute and fractionated irradiation on DCX-positive cell...
متن کاملAdult Hippocampal Neurogenesis and Memory
Adult neurogenesis, a concept emergent in the late 1990s, is the generation of new neurons in the adult brain. This process occurs thank to cells who have this proliferative feature, named as Neural Stem Cells (NSCs). Neural Stem Cells (NSCs) are primary progenitors who can generate the two neural types (neurons and glia). Classically it was assumed that NSCs are only present in the embryo, but...
متن کاملAdult Hippocampal Neurogenesis and Memory
Adult neurogenesis, a concept emergent in the late 1990s, is the generation of new neurons in the adult brain. This process occurs thank to cells who have this proliferative feature, named as Neural Stem Cells (NSCs). Neural Stem Cells (NSCs) are primary progenitors who can generate the two neural types (neurons and glia). Classically it was assumed that NSCs are only present in the embryo, but...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2013
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2012.09.010